Publications

  • Parminder K Ruprah and Mark Humphries. In Rodd’s Chemistry of Carbon Compounds, Malcolm Sainsbury, Ed., Elsevier, 1998, Vol. IV, Heterocyclic Chemistry, Chap.37, pages 147-178. Fused Heterocyclic Systems having a Nitrogen Atom Common to Two or More Rings.

 

  • Parminder K Ruprah et al, Eur. J. Org. Chem., 2002, 18, 3145-52. Studies towards the total synthesis of cycloaraneosene and ophiobolin M: a general strategy for the construction of the 5-​8 bicyclic ring system.

 

  • Justine Y.Q. Lai, Steven Langston, Ruth Adams, Rebekah E. Beevers, Richard Boyce, Svenja Burckhardt, James Cobb, Yvonne Ferguson, Eva Figueroa, Neil Grimster, Andrew H. Henry, Nawaz Khan, Kerry Jenkins, Mark W. Jones, Robert Judkins, Jeremy Major, Abid Masood, James Nally, Helen Payne, Lloyd Payne, Gilles Raphy, Tony Raynham, John Reader, Valérie Reader, Alison Reid, Parminder Ruprah, Michael Shaw, Hannah Sore, Matthew Stirling, Adam Talbot, Jess Taylor, Stephen Thompson, Hiroki Wada, David Walker, Medicinal Research Reviews, 2004, 25 (3), 310-330. Preparation of kinase-biased compounds in the search for lead inhibitors of kinase targets.

 

  • P.K. Pooni and G.A. Showell, Mini-Reviews in Medicinal Chemistry, 2006, 6 (10), 1169-1177. Silicon Switches of Marketed Drugs.

 

  • Matthew J. Barnes, Richard Conroy, David J. Miller, John S. Mills, John G. Montana, Parminder K. Pooni, Graham A. Showell, Louise M. Walsh and Julie B. H. Warneck, Bioorg. Med. Chem. Lett., 2007, 17(2) 354. Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase. A new use of silicon bioisosteres in medicinal chemistry

 

  • Parminder K. Pooni, Matthew J. Barnes, David J. Miller, John S. Mills, John G. Montana, Julie B. H.  Warneck and Graham A. Showell. Poster: Johnson & Johnson Pharmaceutical Research & Development and the University of Antwerp Medicinal Chemistry Conference, April 2005, Silicon in the drug discovery process: addressing the need for novel chemical space.

 

  • Posters and presentation at internal global Takeda International Global conference, 2008 and 2010.

 

  • External presentations on drug discovery at academic institutions: : University of East Anglia, Chemistry Department March 2013; Medicinal Chemistry: The magic of getting a white solid; University of Cambridge 2004, 2005, 2006: Medicinal Chemistry and Drug Discovery

 

  • Montana, John Gary; Ruprah, Parminder Kaur; Showell, Graham Andrew; Walsh, Louise Marie. WO/2004/113353. Silicon- comprising aminothiazole derivatives as CDK inhibitors

 

  • Miller, David John; Ruprah, Parminder Kaur; Showell, Graham Andrew; Walsh, Louise Marie. WO/2005/005442. Preparation of heterocyclic substituted aryl silicon compounds and their therapeutic use.

 

  • Showell, Graham Andrew; Ruprah, Parminder Kaur; Walsh, Louise Marie. WO/2005/035541. Silylated oxazolylethenyl-​thiazolamine derivatives as potential cyclin-​dependent kinase inhibitors for use in cancer and infection therapy.

 

  • Pooni, Parminder Kaur; Merchant, Kevin John; Kerr, Catrina; Crosby, Stuart Richard; Okawa, Tomohiro; Sasaki, Mitsuru; Gotou, Mika; Showell, Graham Andrew; Teall, Martin Richard. WO/2010/007382. Preparation of benzazepine derivatives for use as histamine H3 antagonists.

 

  • Pooni, Parminder Kaur; Merchant, Kevin John; Buffham, William John. WO/2011/083314. Preparation of benzazepine derivatives as modulators of histamine H3 receptor for the treatment of central nervous system disorders.

 

  • Pooni, Parminder Kaur; Merchant, Kevin John; Maine, Stephanie Anne; Fieldhouse, Charlotte; Showell, Graham Andrew. WO/2011/083315. Preparation of benzazepinylmethyl amides as histamine H3 receptor modulators.

 

  • Pooni, Parminder Kaur; Merchant, Kevin John; Kerr, Catrina Morvern; Harrison, David. WO/2011/083316. Preparation of benzazepine derivatives as modulators of histamine H3 receptor for the treatment of central nervous system disorders.

 

  • Pooni, Parminder Kaur; Merchant, Kevin John. WO/2011/121309. Preparation of phenyl sulfone derivatives as histamine H3 antagonists for treating central nervous system disorders

 

  • Ruprah, Parminder Kaur; Merchant, Kevin John; Walsh, Louise Marie; Kerr, Catrina Morven; Fieldhouse, Charlotte; Harrisson, David; Maine, Stephanie; Hazel, Katherine. WO/2013/027001. Preparation of piperidinylalkene and analogs derivatives as modulators of histamine H3 receptor for the treatment of H3 related disorders, especially central nervous system disorders.

 

  • GB patent application 2016. Therapeutic compounds.